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Vanherwegen et al [88] found that human monocyte-derived dendritic cells treated with 1,25(OH) 2 D 3 displayed a stable tolerogenic phenotype with increased inhibitory molecules including PD-L1

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In the dosing conditions trial, 599 AEs were reported in 134 subjects (85%)

Because the triple-receptor design distinguishes it from earlier single- and dual-agonist peptides, the published literature has grown along an unusually legible arc: a founding discovery paper, a structural-biology study resolving how one peptide can occupy three distinct receptor complexes, and a sequence of clinical trials that broadened from glycemic endpoints into obesity and liver-fat endpoints